๐ง ๆ่ใใใใใจใขใซใใใคใใผ็ ใฎ้ขไฟ
ใขใซใใใคใใผ็ ใฏใไธปใซTauใฟใณใใฏ่ณชใจใขใใญใคใฮฒใซใใฃใฆๅผใ่ตทใใใใ็ฅ็ตๅคๆง็พๆฃใงใใ็พๅจใ็็ถใ็ทฉๅใใใใใฎๆฒป็ๆณใฏๅญๅจใใพใใใ็ ๆฐใฎ้ฒ่กใ้ฒใใใใฎๆฒป็ๆณใฏใพใ ็ขบ็ซใใใฆใใพใใใๆ่ฟใฎ็ ็ฉถใงใฏใๆ่ใใใใใTauใฎๅ้ใๆๅถใใใขใซใใใคใใผ็ ใฎ็ ๆ ใ่ชฟ็ฏใใๅฏ่ฝๆงใ็คบๅใใใฆใใพใใๆฌ่จไบใงใฏใใใใใฎ็ ็ฉถใฎๆฆ่ฆใจใใฎๆ็พฉใซใคใใฆ่ฉณใใ่งฃ่ชฌใใพใใ
๐ ็ ็ฉถๆฆ่ฆ
ๆฌ็ ็ฉถใฏใๆ่ใใใใใTauใฟใณใใฏ่ณชใฎๅ้ใๆๅถใใใขใซใใใคใใผ็ ใฎ็ ๆ ใซใฉใฎใใใซ้ขไธใใใใๆขใใใจใ็ฎ็ใจใใฆใใพใใ็นใซใๆ่ใใใใใฎๅฝนๅฒใๆฒป็็ๅๅญใใใคใชใใผใซใผใจใใฆใฎๅฏ่ฝๆงใๆใคใใจใซ็ฆ็นใๅฝใฆใฆใใพใใ
๐ฌ ๆนๆณ
็ ็ฉถใงใฏใๆ่ใใใใใฎๅนๆใ่ฉไพกใใใใใซใใใพใใพใชๅฎ้จๆๆณใ็จใใใใพใใใๅ ทไฝ็ใซใฏใTauใฟใณใใฏ่ณชใฎๅ้ใ่ฆณๅฏใใๆ่ใใใใใใใฎ้็จใซไธใใๅฝฑ้ฟใๅๆใใพใใใใพใใใขใซใใใคใใผ็ ๆฃ่ ใจๅฅๅธธ่ ใฎไฝๆถฒไธญใฎๆ่ใใใใใฎใฌใใซใฎๅคๅใ่ชฟๆปใใใพใใใ
๐ ไธปใชใใคใณใ
| ่ฆ็ด | ็ตๆ |
|---|---|
| ๆ่ใใใใใฎ็จฎ้ก | ใฉใฏใใใงใชใณใLL-37ใใใฃใใงใณใทใณ |
| Tauๅ้ใฎๆๅถ | ๆ่ใใใใใTauใฎๅ้ใๆๅถใใใใจใ็ขบ่ชใใใ |
| ็ ๆ ่ชฟ็ฏ | ๆ่ใใใใใใขใซใใใคใใผ็ ใฎ็ ๆ ใซๅฝฑ้ฟใไธใใๅฏ่ฝๆงใใใ |
| ไฝๆถฒไธญใฎๅคๅ | ADๆฃ่ ใจๅฅๅธธ่ ใงใฎๆ่ใใใใใฌใใซใฎ้ใ |
๐งช ่ๅฏ
ๆ่ใใใใใฏใใขใซใใใคใใผ็ ใซใใใฆ้่ฆใชๅฝนๅฒใๆใใๅฏ่ฝๆงใใใใพใใ็นใซใใใใใฎใใใใใTauใฟใณใใฏ่ณชใฎๅ้ใๆๅถใใใใจใงใ็ฅ็ตๅคๆงใฎ้ฒ่กใ้ ใใใๅฏ่ฝๆงใใใใใใไปๅพใฎ็ ็ฉถใๆๅพ ใใใพใใใพใใๆ่ใใใใใฎใฌใใซใใขใซใใใคใใผ็ ใฎ้ฒ่กใซ้ข้ฃใใฆใใใใจใใใใใใใๆฐใใชใใคใชใใผใซใผใจใใฆใฎๅฉ็จใ่ใใใใพใใ
๐ก ๅฎ็ๆดปใขใใใคใน
- ๆ่ใใใใใๅซใ้ฃๅ๏ผไพ๏ผไนณ่ฃฝๅใ็นๅฎใฎ่้ก๏ผใ็ฉๆฅต็ใซๆๅใใใ
- ่ ธๅ ็ฐๅขใๆดใใใใใซใ็บ้ ต้ฃๅใๅใๅ ฅใใใ
- ในใใฌใน็ฎก็ใ้ฉๅบฆใช้ๅใๅฟใใใๅ จไฝ็ใชๅฅๅบทใ็ถญๆใใใ
โ ๏ธ ้็/่ชฒ้ก
ๆฌ็ ็ฉถใซใฏใใใคใใฎ้็ใใใใพใใใพใใๆ่ใใใใใฎใกใซใใบใ ใๅนๆใฎ่ฉณ็ดฐใฏใพใ ๅฎๅ จใซใฏ่งฃๆใใใฆใใพใใใใพใใ่จๅบ่ฉฆ้จใซๅใใๅฎ็จๅใซใฏใใใชใ็ ็ฉถใๅฟ ่ฆใงใใใใใใฎ็นใ่ธใพใใไปๅพใฎ็ ็ฉถใ้่ฆใงใใ
ใพใจใ
ๆ่ใใใใใฏใTauใฟใณใใฏ่ณชใฎๅ้ใๆๅถใใใขใซใใใคใใผ็ ใฎ็ ๆ ใซๅฝฑ้ฟใไธใใๅฏ่ฝๆงใใใใใจใ็คบใใใพใใใไปๅพใฎ็ ็ฉถใซใใฃใฆใใใใใฎใใใใใๆฐใใชๆฒป็ๆณใใใคใชใใผใซใผใจใใฆใฎๅฝนๅฒใๆใใใใจใๆๅพ ใใใพใใ
้ข้ฃใชใณใฏ้
ๅ่ๆ็ฎ
| ๅ้ก | Antimicrobial peptides inhibit Tau aggregation and modulates its pathology. |
|---|---|
| ๆฒ่ผ่ช(ๅนด) | Adv Protein Chem Struct Biol (2026) |
| DOI | doi: 10.1016/bs.apcsb.2025.09.002 |
| PubMed URL | https://pubmed.ncbi.nlm.nih.gov/41581938/ |
| PMID | 41581938 |
ๆธ่ชๆ ๅ ฑ
| DOI | 10.1016/bs.apcsb.2025.09.002 |
|---|---|
| PMID | 41581938 |
| PubMed URL | https://pubmed.ncbi.nlm.nih.gov/41581938/ |
| ็บ่กๅนด | 2026 |
| ่่ ๅ | Chinnathambi Subashchandrabose, Rangappa Nagaraj, Malik Sneha |
| ่่ ๆๅฑ | Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Institute of National Importance, Bangalore, Karnataka, India. Electronic address: subashneuro@nimhans.ac.in. / Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Institute of National Importance, Bangalore, Karnataka, India. |
| ้่ชๅ | Advances in protein chemistry and structural biology |