ใ‚ใ‹ใ‚‹ๅŒปๅญฆ่ซ–ๆ–‡
  • ใƒ›ใƒผใƒ 
ๆ–ฐ็€่ซ–ๆ–‡ ใ‚ตใ‚คใƒˆใƒžใƒƒใƒ—
2026.01.26 ่„ณๅ’ไธญใƒป่ช็Ÿฅ็—‡ใƒป็ฅž็ตŒ็–พๆ‚ฃ

ใ‚ขใƒซใƒ„ใƒใ‚คใƒžใƒผ็—…ใซใŠใ‘ใ‚‹ๆŠ—่Œใƒšใƒ—ใƒใƒ‰ใฎๅฝนๅ‰ฒ

Antimicrobial peptides act as a component of brain immunity against microbes in Alzheimer's disease.

TOP ๏ผž ่„ณๅ’ไธญใƒป่ช็Ÿฅ็—‡ใƒป็ฅž็ตŒ็–พๆ‚ฃ ๏ผž ่จ˜ไบ‹่ฉณ็ดฐ

๐Ÿง  ใ‚ขใƒซใƒ„ใƒใ‚คใƒžใƒผ็—…ใซใŠใ‘ใ‚‹ๆŠ—่Œใƒšใƒ—ใƒใƒ‰ใฎๅฝนๅ‰ฒ

ใ‚ขใƒซใƒ„ใƒใ‚คใƒžใƒผ็—…ใฏใ€้ซ˜้ฝข่€…ใซใŠใ‘ใ‚‹ๆœ€ใ‚‚ไธ€่ˆฌ็š„ใช่ช็Ÿฅ็—‡ใฎไธ€ใคใงใ™ใ€‚ๆœ€่ฟ‘ใฎ็ ”็ฉถใงใฏใ€ใ‚ขใƒซใƒ„ใƒใ‚คใƒžใƒผ็—…ใฎ็™บ็—‡ใซใŠใ„ใฆใ€ๆŠ—่Œใƒšใƒ—ใƒใƒ‰๏ผˆAMPs๏ผ‰ใŒๆžœใŸใ™ๅฝนๅ‰ฒใซๆณจ็›ฎใŒ้›†ใพใฃใฆใ„ใพใ™ใ€‚ๆœฌ่จ˜ไบ‹ใงใฏใ€ๆœ€่ฟ‘ใฎ็ ”็ฉถใ‚’ๅŸบใซใ€AMPsใŒ่„ณใฎๅ…็–ซใซใฉใฎใ‚ˆใ†ใซๅฏ„ไธŽใ™ใ‚‹ใ‹ใ‚’ๆŽขใ‚Šใพใ™ใ€‚

๐Ÿงฌ ็ ”็ฉถๆฆ‚่ฆ

ๆœฌ็ ”็ฉถใงใฏใ€ใ‚ขใƒซใƒ„ใƒใ‚คใƒžใƒผ็—…ใซใŠใ‘ใ‚‹ๆŠ—่Œใƒšใƒ—ใƒใƒ‰ใฎๅฝนๅ‰ฒใ‚’ๆคœ่จŽใ—ใฆใ„ใพใ™ใ€‚็‰นใซใ€ใ‚ขใƒŸใƒญใ‚คใƒ‰ฮฒ๏ผˆAฮฒ๏ผ‰ใจใ‚ฟใ‚ฆใ‚ฟใƒณใƒ‘ใ‚ฏ่ณชใฎ่“„็ฉใŒใ‚ขใƒซใƒ„ใƒใ‚คใƒžใƒผ็—…ใฎ็™บ็—‡ใซ้–ขไธŽใ—ใฆใ„ใ‚‹ใ“ใจใŒ็คบใ•ใ‚Œใฆใ„ใพใ™ใ€‚ใพใŸใ€ๆœ€่ฟ‘ใฎ่‡จๅบŠ็ ”็ฉถใงใฏใ€็‰นๅฎšใฎ็—…ๅŽŸๅพฎ็”Ÿ็‰ฉใŒใ‚ขใƒซใƒ„ใƒใ‚คใƒžใƒผ็—…ๆ‚ฃ่€…ใซๅญ˜ๅœจใ™ใ‚‹ใ“ใจใŒ็ขบ่ชใ•ใ‚ŒใฆใŠใ‚Šใ€ๆ„ŸๆŸ“ไปฎ่ชฌใŒๅผทๅŒ–ใ•ใ‚Œใฆใ„ใพใ™ใ€‚

๐Ÿ”ฌ ๆ–นๆณ•

ใ“ใฎใƒฌใƒ“ใƒฅใƒผใฏใ€ๆŠ—่Œใƒšใƒ—ใƒใƒ‰ใฎ็‰นๆ€งใ‚’ๆ˜Žใ‚‰ใ‹ใซใ™ใ‚‹ใŸใ‚ใซใ€ใ•ใพใ–ใพใชๆ–‡็Œฎใ‚’่ชฟๆŸปใ—ใ€ใ‚ขใƒซใƒ„ใƒใ‚คใƒžใƒผ็—…ใซ้–ข้€ฃใ™ใ‚‹ๅพฎ็”Ÿ็‰ฉใฎๅฝฑ้Ÿฟใ‚’่€ƒๅฏŸใ—ใฆใ„ใพใ™ใ€‚็‰นใซใ€ๆŒ็ถš็š„ใช็ดฐ่Œใ‚„ใ‚ฆใ‚คใƒซใ‚นๆ„ŸๆŸ“ใŒ่ก€ๆถฒ่„ณ้–ข้–€๏ผˆBBB๏ผ‰ใฎ้€้Žๆ€งใ‚’ๅค‰ๅŒ–ใ•ใ›ใ€่„ณๅ†…ใงใฎ็—…ๅŽŸไฝ“ใฎๅฎš็€ใ‚’ๅฎนๆ˜“ใซใ™ใ‚‹ใƒกใ‚ซใƒ‹ใ‚บใƒ ใซ็„ฆ็‚นใ‚’ๅฝ“ใฆใฆใ„ใพใ™ใ€‚

๐Ÿ“Š ไธปใชใƒใ‚คใƒณใƒˆ

่ฆ็ด  ่ฉณ็ดฐ
ใ‚ขใƒซใƒ„ใƒใ‚คใƒžใƒผ็—…ใฎ็‰นๅพด ใ‚ขใƒŸใƒญใ‚คใƒ‰ฮฒใจใ‚ฟใ‚ฆใ‚ฟใƒณใƒ‘ใ‚ฏ่ณชใฎ่“„็ฉ
ๆŠ—่Œใƒšใƒ—ใƒใƒ‰ใฎๅฝนๅ‰ฒ ็—…ๅŽŸไฝ“ใซๅฏพใ™ใ‚‹ๆŠ—่Œๆดปๆ€งใฎๆไพ›
ๆ„ŸๆŸ“ไปฎ่ชฌ ็—…ๅŽŸๅพฎ็”Ÿ็‰ฉใŒใ‚ขใƒซใƒ„ใƒใ‚คใƒžใƒผ็—…ใซ้–ขไธŽ
่ก€ๆถฒ่„ณ้–ข้–€ใฎๅค‰ๅŒ– ็—…ๅŽŸไฝ“ใฎ่„ณๅ†…ๅฎš็€ใ‚’ไฟƒ้€ฒ

๐Ÿ’ญ ่€ƒๅฏŸ

ๆŠ—่Œใƒšใƒ—ใƒใƒ‰ใฏใ€่„ณๅ†…ใฎๅ…็–ซๅฟœ็ญ”ใซใŠใ„ใฆ้‡่ฆใชๅฝนๅ‰ฒใ‚’ๆžœใŸใ™ๅฏ่ƒฝๆ€งใŒใ‚ใ‚Šใพใ™ใ€‚ใ‚ขใƒŸใƒญใ‚คใƒ‰ฮฒใฏใ€็—…ๅŽŸไฝ“ใซๅฏพๆŠ—ใ™ใ‚‹ใŸใ‚ใซๅ‡้›†ใ—ใ€ๆ„ŸๆŸ“ใซๅฏพใ™ใ‚‹้˜ฒๅพกๆฉŸๆง‹ใ‚’ๅผทๅŒ–ใ™ใ‚‹ใ“ใจใŒ็คบๅ”†ใ•ใ‚Œใฆใ„ใพใ™ใ€‚ใ—ใ‹ใ—ใ€ๅŒๆ™‚ใซใ€ๅพฎ็”Ÿ็‰ฉใ‚‚ใ‚ขใƒŸใƒญใ‚คใƒ‰ใƒ•ใ‚ฃใƒ–ใƒชใƒซใ‚’ๅฝขๆˆใ—ใ€็’ฐๅขƒใ‹ใ‚‰ใฎ็ดฐ่ƒžใ‚’ๅฎˆใ‚‹ใŸใ‚ใฎใƒใ‚คใ‚ชใƒ•ใ‚ฃใƒซใƒ ใ‚’ไฝœใ‚‹ใ“ใจใŒใ‚ใ‚Šใพใ™ใ€‚ใ“ใฎใ‚ˆใ†ใซใ€ใ‚ขใƒซใƒ„ใƒใ‚คใƒžใƒผ็—…ใซใŠใ‘ใ‚‹AMPsใฎๅฝนๅ‰ฒใฏใ€ๅ˜ใชใ‚‹้˜ฒๅพกใ ใ‘ใงใชใใ€็—…ๅŽŸไฝ“ใจใฎ็›ธไบ’ไฝœ็”จใซใ‚‚้–ขไธŽใ—ใฆใ„ใ‚‹ใจ่€ƒใˆใ‚‰ใ‚Œใพใ™ใ€‚

๐Ÿ“ ๅฎŸ็”Ÿๆดปใ‚ขใƒ‰ใƒใ‚คใ‚น

  • ๅฅๅบท็š„ใช้ฃŸไบ‹ใ‚’ๅฟƒใŒใ‘ใ€ๆŠ—็‚Ž็—‡ไฝœ็”จใฎใ‚ใ‚‹้ฃŸๅ“ใ‚’ๆ‘‚ๅ–ใ™ใ‚‹ใ€‚
  • ๅฎšๆœŸ็š„ใช้‹ๅ‹•ใ‚’่กŒใ„ใ€ๅ…็–ซๅŠ›ใ‚’้ซ˜ใ‚ใ‚‹ใ€‚
  • ใ‚นใƒˆใƒฌใ‚น็ฎก็†ใ‚’่กŒใ„ใ€ใƒกใƒณใ‚ฟใƒซใƒ˜ใƒซใ‚นใ‚’็ถญๆŒใ™ใ‚‹ใ€‚
  • ๆ„ŸๆŸ“็—‡ไบˆ้˜ฒใฎใŸใ‚ใฎใƒฏใ‚ฏใƒใƒณๆŽฅ็จฎใ‚’ๆคœ่จŽใ™ใ‚‹ใ€‚

โš ๏ธ ้™็•Œ/่ชฒ้กŒ

ๆœฌ็ ”็ฉถใซใฏใ„ใใคใ‹ใฎ้™็•ŒใŒใ‚ใ‚Šใพใ™ใ€‚ใพใšใ€ๆŠ—่Œใƒšใƒ—ใƒใƒ‰ใฎๅ…ทไฝ“็š„ใชใƒกใ‚ซใƒ‹ใ‚บใƒ ใ‚„ไฝœ็”จใซใคใ„ใฆใฏใพใ ่งฃๆ˜Žใ•ใ‚Œใฆใ„ใชใ„้ƒจๅˆ†ใŒๅคšใใ€ใ•ใ‚‰ใชใ‚‹็ ”็ฉถใŒๅฟ…่ฆใงใ™ใ€‚ใพใŸใ€ใ‚ขใƒซใƒ„ใƒใ‚คใƒžใƒผ็—…ใฎ็™บ็—‡ใซใŠใ‘ใ‚‹ไป–ใฎ่ฆๅ› ใจใฎ็›ธไบ’ไฝœ็”จใซใคใ„ใฆใ‚‚่€ƒๆ…ฎใ™ใ‚‹ๅฟ…่ฆใŒใ‚ใ‚Šใพใ™ใ€‚

ใพใจใ‚

ใ‚ขใƒซใƒ„ใƒใ‚คใƒžใƒผ็—…ใซใŠใ‘ใ‚‹ๆŠ—่Œใƒšใƒ—ใƒใƒ‰ใฎๅฝนๅ‰ฒใฏใ€่„ณใฎๅ…็–ซๅฟœ็ญ”ใซใŠใ„ใฆ้‡่ฆใงใ‚ใ‚Šใ€็—…ๅŽŸไฝ“ใซๅฏพใ™ใ‚‹้˜ฒๅพกๆฉŸๆง‹ใ‚’ๅผทๅŒ–ใ™ใ‚‹ๅฏ่ƒฝๆ€งใŒใ‚ใ‚Šใพใ™ใ€‚ไปŠๅพŒใฎ็ ”็ฉถใŒใ€ใ“ใฎๅˆ†้‡Žใฎ็†่งฃใ‚’ๆทฑใ‚ใ‚‹ใ“ใจใŒๆœŸๅพ…ใ•ใ‚Œใพใ™ใ€‚

๐Ÿ”— ้–ข้€ฃใƒชใƒณใ‚ฏ้›†

  • ใ‚ขใƒซใƒ„ใƒใ‚คใƒžใƒผๅ”ไผš
  • ็ฑณๅ›ฝๅ›ฝ็ซ‹่ก›็”Ÿ็ ”็ฉถๆ‰€๏ผˆNIH๏ผ‰
  • PubMed

ๅ‚่€ƒๆ–‡็Œฎ

ๅŽŸ้กŒ Antimicrobial peptides act as a component of brain immunity against microbes in Alzheimer’s disease.
ๆŽฒ่ผ‰่ชŒ(ๅนด) Adv Protein Chem Struct Biol (2026)
DOI doi: 10.1016/bs.apcsb.2025.10.016
PubMed URL https://pubmed.ncbi.nlm.nih.gov/41581939/
PMID 41581939

ๆ›ธ่ชŒๆƒ…ๅ ฑ

DOI 10.1016/bs.apcsb.2025.10.016
PMID 41581939
PubMed URL https://pubmed.ncbi.nlm.nih.gov/41581939/
็™บ่กŒๅนด 2026
่‘—่€…ๅ Chandrashekar Madhura, Velmurugan Gowshika, Mishra Amit, Chinnathambi Subashchandrabose
่‘—่€…ๆ‰€ๅฑž Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Institute of National Importance, Bangalore, Karnataka, India. / Cellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan, India. / Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Institute of National Importance, Bangalore, Karnataka, India. Electronic address: subashneuro@nimhans.ac.in.
้›‘่ชŒๅ Advances in protein chemistry and structural biology

่ซ–ๆ–‡่ฉ•ไพก

่ฉ•ไพกใƒ‡ใƒผใ‚ฟใชใ—

้–ข้€ฃ่ซ–ๆ–‡

2025.12.28 ่„ณๅ’ไธญใƒป่ช็Ÿฅ็—‡ใƒป็ฅž็ตŒ็–พๆ‚ฃ

่„ณๅ’ไธญๆ‚ฃ่€…ใฎ็คพไผš็š„ๅญค็ซ‹๏ผšๅ‰ๅ‘ใ็ ”็ฉถ

Trajectories and influencing factors of social alienation in first-onset stroke patients: a prospective cohort study.

ๆ›ธ่ชŒๆƒ…ๅ ฑ

DOI 10.1186/s12889-025-26051-3
PMID 41455969
PubMed URL https://pubmed.ncbi.nlm.nih.gov/41455969/
็™บ่กŒๅนด 2025
่‘—่€…ๅ Lin Yinglu, Chen Yanxin, Wu Hanghang, Tian Xinran, Xu Changxin, Li Qi, Lu Panting, Zhang Huafang
้›‘่ชŒๅ BMC public health
2025.12.19 ่„ณๅ’ไธญใƒป่ช็Ÿฅ็—‡ใƒป็ฅž็ตŒ็–พๆ‚ฃ

ใ‚ขใƒซใƒ„ใƒใ‚คใƒžใƒผ็—…ใฎ้€ฒ่กŒใ‚’็›ฃ่ฆ–ใ™ใ‚‹่‡จๅบŠใ‚นใ‚ณใ‚ขใƒขใƒ‡ใƒซ

Development and validation of an interpretable clinical scoring model to monitor the progression of preclinical Alzheimer's disease.

ๆ›ธ่ชŒๆƒ…ๅ ฑ

DOI 10.1186/s13195-025-01931-3
PMID 41413577
PubMed URL https://pubmed.ncbi.nlm.nih.gov/41413577/
็™บ่กŒๅนด 2025
่‘—่€…ๅ Chu Chenyin, Wang Yihan, Ma Liwei, Ouyang Youjian, Zisis Georgios, Masters Colin L, Goudey Benjamin, Jin Liang, Pan Yijun, A4 and LEARN Study Teams
้›‘่ชŒๅ Alzheimer's research & therapy
2025.12.14 ่„ณๅ’ไธญใƒป่ช็Ÿฅ็—‡ใƒป็ฅž็ตŒ็–พๆ‚ฃ

ๅนน็ดฐ่ƒžใฎ้€ฒๅŒ–๏ผš2019ๅนดใ‹ใ‚‰2024ๅนดใฎใ‚ขใƒซใƒ„ใƒใ‚คใƒžใƒผ็—…ใจใƒ‘ใƒผใ‚ญใƒณใ‚ฝใƒณ็—…ๆฒป็™‚ใจใƒขใƒ‡ใƒซๅŒ–ใฎๅ–ใ‚Š็ต„ใฟ

Stem cells strike back: advancements in Alzheimer's and Parkinson's disease treatment and modeling efforts from 2019 to 2024.

ๆ›ธ่ชŒๆƒ…ๅ ฑ

DOI 10.1007/s00109-025-02613-1
PMID 41389269
PubMed URL https://pubmed.ncbi.nlm.nih.gov/41389269/
็™บ่กŒๅนด 2025
่‘—่€…ๅ Isakoviฤ‡ Jasmina, Athanassiadis Anna, Khubeis Marian
้›‘่ชŒๅ Journal of molecular medicine (Berlin, Germany)
  • ใŒใ‚“ใƒป่…ซ็˜ๅญฆ
  • ใƒกใƒณใ‚ฟใƒซใƒ˜ใƒซใ‚น
  • ๅ…็–ซ็™‚ๆณ•
  • ๅŒป็™‚AI
  • ๅ‘ผๅธๅ™จ็–พๆ‚ฃ
  • ๅนน็ดฐ่ƒžใƒปๅ†็”ŸๅŒป็™‚
  • ๅพช็’ฐๅ™จใƒปๅฟƒ่‡“็—…
  • ๆ„ŸๆŸ“็—‡ๅ…จ่ˆฌ
  • ๆบๅธฏ้›ป่ฉฑ้–ข้€ฃ๏ผˆใ‚นใƒžใƒผใƒˆใƒ•ใ‚ฉใƒณ๏ผ‰
  • ๆ–ฐๅž‹ใ‚ณใƒญใƒŠใ‚ฆใ‚คใƒซใ‚นๆ„ŸๆŸ“็—‡
  • ๆ „้คŠใƒป้ฃŸไบ‹
  • ็ก็œ ็ ”็ฉถ
  • ็ณ–ๅฐฟ็—…
  • ่‚ฅๆบ€ใƒปไปฃ่ฌ็•ฐๅธธ
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  • ่…ธๅ†…็ดฐ่Œ
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