๐ง ่ณ่ ซ็ใฎๅ ็ซ็ฃ่ฆใจใใๅ ็ซ็ๆณใๅไธใใใใใใฎ่ ซ็ๅ ๅฃๆญป่่ณชๆพๅบใฎๆจ็ๅ
่ณ่ ซ็ใ็นใซ็ฅ็ต่ ่ ซ๏ผGBM๏ผใฏใๅ ็ซ็ณปใใใฎๆปๆใๅ้ฟใใใใใซ้ฒๅใใๅ ็ซๆๅถ็ใชๅพฎๅฐ็ฐๅขใ็ขบ็ซใใพใใใใใซใใใใใๅ ็ซ็ๆณใฎๅนๆใๅถ้ใใใใใจใใใใพใใๆ่ฟใฎ็ ็ฉถใงใฏใ่ ซ็ๅ ใฎๅฃๆญปใ่่ณชใฎๆพๅบใๅผใ่ตทใใใใใใๅ ็ซ็ฃ่ฆใซใฉใฎใใใซๅฝฑ้ฟใไธใใใใๆใใใซใใใพใใใๆฌ่จไบใงใฏใ่ ซ็ๅ ๅฃๆญป่่ณชๆพๅบใฎๆจ็ๅใ่ณ่ ซ็ใซใใใๅ ็ซ็ฃ่ฆใจใใๅ ็ซ็ๆณใใฉใฎใใใซๅไธใใใใใซใคใใฆ่ฉณใใ่งฃ่ชฌใใพใใ
๐ฌ ็ ็ฉถๆฆ่ฆ
ใใฎ็ ็ฉถใฏใใใฆในใฎ่ ซ็ใขใใซใ็จใใฆใใใใฎๅ ็ซ้้ฟใจใใๅ ็ซ็ๆณใฎใในใใ่กใใพใใใ็นใซใ้็ๆงใฎใใฆใน่ๆงๅนน็ดฐ่ใใๆดพ็ใใ่ ซ็ใขใใซใ้็บใใCRISPRในใฏใชใผใใณใฐใ้ใใฆใใใฎๅ ็ซ็ทจ้ใซๅฝฑ้ฟใไธใใ้บไผๅญใ็นๅฎใใพใใใ
๐งช ๆนๆณ
็ ็ฉถ่ ใใกใฏใ่ ซ็ๆๅถ้บไผๅญใฎๅชๅคฑใ่ ซ็ๅ ใฎๅฃๆญปใๅผใ่ตทใใใAPOE่่ณช็ฒๅญใ็ดฐ่ๅคใซๆพๅบใใใใใจใ็บ่ฆใใพใใใใใใซใ่ ซ็ๅ ใฎๅฃๆญปใใ้ ๅใซๅผใๅฏใใใใT็ดฐ่ใฏ่่ณชใ่็ฉใใๆฉ่ฝไธๅ จใซ้ฅใใพใใใใใใใฎ็พ่ฑกใ้ปๆญขใใใใจใงใๅ ็ซ็ฃ่ฆใๅๅพฉใใใใจใ็คบใใใพใใใ
๐ ไธปใช็ตๆ
| ็ตๆ | ่ฉณ็ดฐ |
|---|---|
| ่ ซ็ๆๅถ้บไผๅญใฎๅชๅคฑ | Trp53้บไผๅญใฎๅชๅคฑใ่ ซ็ๅ ใฎๅฃๆญปใๅขๅ ใใใใ |
| APOE่่ณช็ฒๅญใฎๆพๅบ | ๅฃๆญปใใ่ ซ็็ดฐ่ใใAPOE่่ณช็ฒๅญใๆพๅบใใใT็ดฐ่ใๆฉ่ฝไธๅ จใซใ |
| ๅ ็ซ็ฃ่ฆใฎๅๅพฉ | ่่ณชใฎๅใ่พผใฟใ้ปๅฎณใใใใจใงT็ดฐ่ใฎๆฉ่ฝใๅๅพฉใ |
| ใใGBMใซใใใ็ธไบไฝ็จ | TP53ๅค็ฐใๆใคใใGBMใซใใใฆใๅๆงใฎ็พ่ฑกใ็ขบ่ชใใใใ |
| ๆฒป็ๅนๆใฎๅไธ | ๆAPOEใใใณๆPDCD1ๆไฝใฎไฝต็จใๆGBMๅ ็ซใๅผทๅใใ็ๅญๆ้ใๅปถ้ทใ |
๐ญ ่ๅฏ
ใใฎ็ ็ฉถใฏใ่ ซ็ๅ ใฎๅฃๆญปใๅ ็ซ้้ฟใซๅฏไธใใใกใซใใบใ ใๆใใใซใใ็นใซAPOE่่ณช็ฒๅญใT็ดฐ่ใฎๆฉ่ฝใซไธใใๅฝฑ้ฟใ็คบใใฆใใพใใ่ ซ็ๆๅถ้บไผๅญใฎๅชๅคฑใๅฃๆญปใๅผใ่ตทใใใใใใๅ ็ซ็ณปใฎๆฉ่ฝใไฝไธใใใใใจใ็ขบ่ชใใใพใใใไปๅพใฎใใๅ ็ซ็ๆณใงใฏใ่่ณชใฎๅใ่พผใฟใๆจ็ใซใใใใจใงใๅ ็ซ็ฃ่ฆใๅผทๅใใๆฐใใชใขใใญใผใใๆๅพ ใใใพใใ
๐ ๅฎ็ๆดปใขใใใคใน
- ใใๅ ็ซ็ๆณใซ้ขๅฟใใใๆนใฏใๅป็ๆฉ้ขใงใฎๆๆฐใฎๆฒป็ๆณใซใคใใฆ็ธ่ซใใฆใฟใฆใใ ใใใ
- ๅฅๅบท็ใช้ฃ็ๆดปใๅฟใใใๅ ็ซๅใ้ซใใๆ ้ค็ด ใๆ่ญ็ใซๆๅใใพใใใใ
- ๅฎๆ็ใช้ๅใฏๅ ็ซๆฉ่ฝใใตใใผใใใพใใฎใงใๆฅๅธธ็ใซไฝใๅใใใใจใใๅงใใใพใใ
- ในใใฌใน็ฎก็ใ้่ฆใงใใใชใฉใฏใผใผใทใงใณใ่ถฃๅณใฎๆ้ใๅคงๅใซใใพใใใใ
โ ๏ธ ้็/่ชฒ้ก
ๆฌ็ ็ฉถใซใฏใใใคใใฎ้็ใใใใพใใใพใใใใฆในใขใใซใงๅพใใใ็ตๆใใใใซใใฎใพใพ้ฉ็จใงใใใใฏไธๆใงใใใพใใAPOE่่ณช็ฒๅญใฎๅฝนๅฒใใใฎใกใซใใบใ ใซใคใใฆใฎ็่งฃใฏใพใ ไธๅฎๅ จใงใใใใใใชใ็ ็ฉถใๅฟ ่ฆใงใใๅ ใใฆใๆฒป็ๆณใฎๅฎ็จๅใซใฏๅคใใฎ่จๅบ่ฉฆ้จใๅฟ ่ฆใงใใ
ใพใจใ
่ ซ็ๅ ใฎๅฃๆญป่่ณชๆพๅบใๆจ็ใจใใใใจใใ่ณ่ ซ็ใซใใใๅ ็ซ็ฃ่ฆใจใใๅ ็ซ็ๆณใๅไธใใใๅฏ่ฝๆงใใใใใจใ็คบใใใพใใใไปๅพใฎ็ ็ฉถใใใฎๅ้ใซๆฐใใชๆฒป็ๆณใใใใใใใจใๆๅพ ใใฆใใพใใ
ๅ่ๆ็ฎ
| ๅ้ก | Targeting necrotic lipid release in tumors enhances immunosurveillance and cancer immunotherapy of glioblastoma. |
|---|---|
| ๆฒ่ผ่ช(ๅนด) | Cell Res (2025 Sep 3) |
| DOI | doi: 10.1038/s41422-025-01155-y |
| PubMed URL | https://pubmed.ncbi.nlm.nih.gov/40903538/ |
| PMID | 40903538 |
ๆธ่ชๆ ๅ ฑ
| DOI | 10.1038/s41422-025-01155-y |
|---|---|
| PMID | 40903538 |
| PubMed URL | https://pubmed.ncbi.nlm.nih.gov/40903538/ |
| ็บ่กๅนด | 2025 |
| ่่ ๅ | Ji Yapeng, Jiang Junyao, Hu Lei, Lin Peng, Zhou Mingshan, Hu Song, Wang Minkai, Ji Yuchen, Liu Xianzhi, Yan Dongming, Guo Yang, Sathe Adwait Amod, Evers Bret M, Xing Chao, Luo Xuelian, Xie Qi, Pei Weike, Zhang Zhenyu, Yu Hongtao |
| ่่ ๆๅฑ | Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China. / School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China. / New Cornerstone Science Laboratory, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China. / Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. / Department of Neurosurgery, Henan Provincial People's Hospital, Zhengzhou, Henan, China. / Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA. / Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA. / Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA. / Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. fcczhangzy1@zzu.edu.cn. / Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China. yuhongtao@westlake.edu.cn. |
| ้่ชๅ | Cell research |